Induction of insulin resistance by phosphatidylinositol-3-kinase inhibitor in porcine granulosa cells
作者： Miaoe Yan , Jing Wang , Xiaoke Wu , Lihui Hou , Haixue Kuang
DOI: 10.1016/J.FERTNSTERT.2009.06.019
关键词:
摘要: Insulin resistance on porcine granulosa cells was induced by wortmannin, the phosphatidylinositol-3-kinase inhibitor, and insulin signaling key molecules were investigated including glut 4 mitogen-activated protein kinase. Granulosa decreased expression but increased kinase, indicating cross talk between metabolic mitogenic pathways of in ovary.
fertstert.org
elsevier.com
sci-hub.se 参考文章(15)
Aurel Fet¸eanu, Ilie Marcu, Despina Tudor, Ilie Gabriel, Labelled antibodies in biology and medicine Abacus Press , McGraw-Hill. ,(1978)
Santo V. Nicosia, Joseph R. Testa, Richard Jove, Jin Q. Cheng, Ai-xue Liu, Thomas C. Hamilton, AKT2, a Member of the Protein Kinase B Family, Is Activated by Growth Factors, v-Ha-ras, and v-src through Phosphatidylinositol 3-Kinase in Human Ovarian Epithelial Cancer Cells Cancer Research. ,vol. 58, pp. 2973- 2977 ,(1998)
JunWei Qu, Yong Wang, Xiaoke Wu, Lei Gao, Lihui Hou, Risto Erkkola, Insulin Resistance Directly Contributes to Androgenic Potential Within Ovarian Theca Cells Fertility and Sterility. ,vol. 91, pp. 1990- 1997 ,(2009) , 10.1016/J.FERTNSTERT.2008.02.167
Monica Montagnani, Inga Golovchenko, Injune Kim, Gou Young Koh, Marc L. Goalstone, Ameya N. Mundhekar, Mette Johansen, Dennis F. Kucik, Michael J. Quon, Boris Draznin, Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells. Journal of Biological Chemistry. ,vol. 277, pp. 1794- 1799 ,(2002) , 10.1074/JBC.M103728200
Evanthia Diamanti-Kandarakis, Athanasios G. Papavassiliou, Molecular mechanisms of insulin resistance in polycystic ovary syndrome Trends in Molecular Medicine. ,vol. 12, pp. 324- 332 ,(2006) , 10.1016/J.MOLMED.2006.05.006
Evanthia Diamanti-Kandarakis, Georgia Argyrakopoulou, Frangiskos Economou, Eleni Kandaraki, Michael Koutsilieris, Defects in insulin signaling pathways in ovarian steroidogenesis and other tissues in polycystic ovary syndrome (PCOS) The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 109, pp. 242- 246 ,(2008) , 10.1016/J.JSBMB.2008.03.014
Xiao Ke Wu, Shan Ying Zhou, Jin Xia Liu, Pasi Pöllänen, Kirsimarja Sallinen, Marjaana Mäkinen, Risto Erkkola, Selective ovary resistance to insulin signaling in women with polycystic ovary syndrome Fertility and Sterility. ,vol. 80, pp. 954- 965 ,(2003) , 10.1016/S0015-0282(03)01007-0
Iqbal Munir, Hui-Wen Yen, David H. Geller, Donna Torbati, Rebecca M. Bierden, Stacy R. Weitsman, Sanjay K. Agarwal, Denis A. Magoffin, Insulin Augmentation of 17α-Hydroxylase Activity Is Mediated by Phosphatidyl Inositol 3-Kinase But Not Extracellular Signal-Regulated Kinase-1/2 in Human Ovarian Theca Cells Endocrinology. ,vol. 145, pp. 175- 183 ,(2004) , 10.1210/EN.2003-0329
Antti Virkamäki, Kohjiro Ueki, C. Ronald Kahn, Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance Journal of Clinical Investigation. ,vol. 103, pp. 931- 943 ,(1999) , 10.1172/JCI6609
Andrea Dunaif, Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Reviews. ,vol. 18, pp. 774- 800 ,(1997) , 10.1210/EDRV.18.6.0318