Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance System.
作者： Hyo Min Cho , Jae Ryun Ryu , Youhwa Jo , Tae Woong Seo , Ye Na Choi
DOI: 10.1016/J.MOLCEL.2018.11.009
关键词:
摘要: Summary Mitophagy, a mitochondrial quality control process for eliminating dysfunctional mitochondria, can be induced by response of dynamin-related protein 1 (Drp1) to reduction in membrane potential (MMP) and division. However, the coordination between MMP division selecting damaged portion network is less understood. Here, we found that reduced focally at fission site Drp1 recruitment, which initiated interaction with zinc transporter Zip1 Zn2+ entry through Zip1-MCU complex. After division, healthy mitochondria restore levels participate fusion-fission cycle again, but fail undergo mitophagy. Thus, interfering blocks of MMP subsequent mitophagic selection mitochondria. These results suggest Drp1-dependent provides selective pressure “bad sectors” network, serving as surveillance system.
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