Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner.

摘要: Exposure of animal body parts to ionizing radiation (IR) can lead molecular changes in distant shielded "bystander" tissues and organs. Nevertheless, tissue specificity bystander responses within the same organism has not been examined detail. Studies on vivo effect conducted so far analyzed induced by single-dose exposure. The potential fractionated irradiation induce effects never studied. We global DNA methylation microRNAome skin spleen animals subjected (acute or fractionated) whole-body cranial exposure 0.5 Gy X-rays. found that IR-induced were distinct. Acute resulted a significant loss exposed 6 hr, 96 14 days after irradiation. Fractionated led hypomethylation hr exposure, Contrarily, seen only acute head observed was paralleled reduction methyl-binding protein MeCP2 expression. Irradiation also tissue-specific alterations spleen. For first time, we have shown epigenetic occur are triggered both very distinct different Future studies clearly needed address organismal carcinogenic repercussions those changes.