作者: N. Gemund , S. Scherjon , S. le Cessie , J.H. Schagen van Leeuwen , J. Roosmalen
DOI: 10.1046/J.1471-0528.2003.00010.X
关键词:
摘要: Objective To compare vaginal misoprostol with dinoprostone for induction of labour. Design Randomised multicentre trial. Setting Labour wards one university hospital and two teaching hospitals. Population Six hundred eighty-one women indication labour at ≥36 weeks gestation, singleton pregnancy no previous ceasarean section. Methods Misoprostol (25 mcg, hospital-prepared capsule) in the posterior fornix, every four hours, maximum three times daily or gel (1 mg) hours. Oxytocin was administered if necessary. Main outcome measures Primary: ‘adverse neonatal outcome’ (5-minute Apgar score <7 and/or umbilical cord pH <7.15). Secondary: duration, mode delivery patient satisfaction. Results Three forty-one received 340 dinoprostone. The median induction–delivery interval longer group compared versus 19 P= 0.008). caesarean section rate lower group: 16.1%versus 21%, but this difference not statistically significant RR = 0.8 (95% CI 0.6–1.04). ‘Adverse found to be similar both groups: 21% 23% groups. Significantly fewer neonates were admitted NICU 19%versus 26% (RR 0.7, 95% 0.5–0.98). Conclusions dosing regimen is a safe method induction. admission rates group. No could detected satisfaction between