SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway
作者： K. L. Woodford-Richens , A. J. Rowan , P. Gorman , S. Halford , D. C. Bicknell
关键词:
摘要: … lines had no detectable SMAD4 mutation, but all showed allele loss at SMAD4 and or DCC. … loss of SMAD4 protein or SMAD4 mutation, and very few had allelic loss at SMAD4 or DCC, …
harvard.edu
sci-hub.se 参考文章(31)
Robb E. Wilentz, Gloria H. Su, Jia Le Dai, Andrew B. Sparks, Pedram Argani, Taylor A. Sohn, Charles J. Yeo, Scott E. Kern, Ralph H. Hruban, Immunohistochemical labeling for Dpc4 mirrors genetic status in pancreatic adenocarcinomas: A new marker of DPC4 inactivation American Journal of Pathology. ,vol. 156, pp. 37- 43 ,(2000) , 10.1016/S0002-9440(10)64703-7
S Roth, P Laiho, R Salovaara, V Launonen, L A Aaltonen, No SMAD4 hypermethylation in colorectal cancer. British Journal of Cancer. ,vol. 83, pp. 1015- 1019 ,(2000) , 10.1054/BJOC.2000.1387
Carethers Jm, Laghi L, Yashiro M, Boland Cr, Slezak P, Jaramillo E, Saito K, Rubio C, Hirakawa K, Koizumi K, Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Cancer Research. ,vol. 61, pp. 2676- 2683 ,(2001)
Yigong Shi, Akiko Hata, Roger S. Lo, Joan Massagué, Nikola P. Pavletich, A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature. ,vol. 388, pp. 87- 93 ,(1997) , 10.1038/40431
Ian Martin Frayling, Richard Poulsom, Takeo Iwama, Kelly Woodford-Richens, Shirley Hodgson, Barbara Leggett, Joanne Young, Nicholas Wright, Ian Tomlinson, Jill Williamson, Denise Sheer, Richard Houlston, Marco Novelli, Jin Cheon Kim, Yi Thway, Stephen Bevan, Allelic Loss at SMAD4 in Polyps from Juvenile Polyposis Patients and Use of Fluorescence in Situ Hybridization to Demonstrate Clonal Origin of the Epithelium Cancer Research. ,vol. 60, pp. 2477- 2482 ,(2000)
Xin-Hua Feng, Xia Lin, Rik Derynck, Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF‐β The EMBO Journal. ,vol. 19, pp. 5178- 5193 ,(2000) , 10.1093/EMBOJ/19.19.5178
A Kallioniemi, O. Kallioniemi, D Sudar, D Rutovitz, J. Gray, F Waldman, D Pinkel, Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors Science. ,vol. 258, pp. 818- 821 ,(1992) , 10.1126/SCIENCE.1359641
Gregory J. Riggins, Sam Thiagalingam, Ester Rozenblum, Craig L. Weinstein, Scott E. Kern, Stanley R. Hamilton, James K.V. Willson, Sanford D. Markowitz, Kenneth W. Kinzler, Bert Vogelstein, Mad-related genes in the human Nature Genetics. ,vol. 13, pp. 347- 349 ,(1997) , 10.1038/NG0796-347
Y Takagi, H Kohmura, M Futamura, H Kida, H Tanemura, K Shimokawa, S Saji, Somatic alterations of the DPC4 gene in human colorectal cancers in vivo Gastroenterology. ,vol. 111, pp. 1369- 1372 ,(1996) , 10.1053/GAST.1996.V111.PM8898652
Riccardo Fodde, Jeroen Kuipers, Carla Rosenberg, Ron Smits, Menno Kielman, Claudia Gaspar, Johan H. van Es, Cor Breukel, Joop Wiegant, Rachel H. Giles, Hans Clevers, Mutations in the APC tumour suppressor gene cause chromosomal instability Nature Cell Biology. ,vol. 3, pp. 433- 438 ,(2001) , 10.1038/35070129