Reduced expression of fatty acid biosynthesis genes in the prefrontal cortex of patients with major depressive disorder.

摘要: Abstract Background Major depressive disorder (MDD) is associated with central and peripheral deficits in long-chain polyunsaturated fatty acids (LC-PUFA), particularly those the omega-3 acid family. However, etiology of these remains poorly understood, there currently little known about expression genes that mediate biosynthesis MDD patients. Methods The FADS1 (Δ5 desaturase), FADS2 (Δ6 HELO1 [ ELOVL5 ] (elongase), PEX19 (peroxisome), SCD (stearoyl-CoA desaturase [Δ9 desaturase]) was determined postmortem prefrontal cortex patients ( n  = 10) non-psychiatric controls by real-time reverse transcriptase polymerase chain reaction (RT-PCR). Results After correcting for multiple comparisons, mRNA significantly lower relative to (−27%, p  = 0.009), were trends (−30%,  = 0.07), (−37%,  = 0.02), (−43%,  = 0.02). did not differ between (−2%,  = 0.92). There no significant gender effects, reductions FADS1, , greater commit suicide compared suicide. Limitations sample size small, all receiving antidepressant medications. Conclusions Principal involved LC-PUFA monounsaturated are down-regulated Additional studies needed replicate extend findings a larger includes antidepressant-free