Dose-volume relationship of acute and late small bowel toxicity from radiation therapy for prostate cancer: a Veterans Affairs study

摘要: The objective of this study was to characterize the dose-volume relationship small bowel toxicity during prostate radiation therapy in a homogenous Veterans Affairs population using modern IMRT/VMAT techniques. All records patients receiving for cancer at Long Beach Hospital between 2009 and 2011 were analyzed (n = 73). Peritoneal space contents contoured on each slice planning CT scan. A median dose 75.6 Gy delivered with either intensity-modulated (IMRT) or volumetric-modulated arc (VMAT). constraint used V45 < 200 cc. Median follow-up 2.4 years. Toxicity scored CTCAE v4.0 grade acute late toxicity. Seventeen (23 %) experienced 1 Twenty-seven (37 %) 2 There 3 % 10 % no 3 higher mean volume 45 Gy 58 cc, range (2–193 cc). Nineteen (26 %) received greater than 52 Gy, (52–80 Gy) had Multivariate analysis showed that prior abdominal surgery predicted HR = 4.6 (95 % CI 1.24–20.5) p = 0.03. In treated radiation, V45 < 200 cc minimizes However, we show can possibly be exceeded without significant short- long-term complications. Further studies should explore maximum tolerated maximize tumor control increasing profile.