Construction of macroporous magnesium phosphate-based bone cement with sustained drug release

摘要: Abstract Magnesium phosphate-based bone cements (MPBCs) have been widely applied in orthopedic and dental fields owing to their excellent self-setting ability high strength. However, lack of macroporosity poor drug release properties restrict use. In this study, we incorporated various degrees cross-linking gelatine microspheres (GM) into MPBC improved the physicochemical biocompatible properties, biodegradation behaviour composites. Diclofenac sodium (DS) was utilized as a model drug. Through experiments observations, found that GM induced an adjustable setting time (12 min–16 min), compression strength (23 MPa–58 MPa), abundant macropores (30.2%–37.8%) sustained DS with double exponential biphasic kinetic (more than 2 months) Moreover, magnesium calcium ions had synergistic effect on proliferation, osteogenesis differentiation, mineralization gene expression (COL I, OPN, Runx2) MC3T3-E1 cells. Subcutaneous implantation histological analyses indicated MPBC-GM composites activated angiogenesis without inducing severe inflammatory reactions. brief, prepared formation macropores, degradation behaviour.