Cytoskeletal abnormalities in motor neuron disease. An immunocytochemical study.

摘要: Immunocytochemistry with antibodies against cytoskeletal proteins has been used to search for molecular differences in the spinal cord from patients motor neuron disease (MND) of amyotrophic lateral sclerosis type and normal cord. Monoclonal which recognize phosphorylated neurofilament epitopes diffusely labelled a proportion MND anterior horn cells, but did not permit differentiation between tissue. However, some control dense 'floccular' accumulations were by recognizing epitopes. These neurofilaments suggest abnormalities regulation, neither common nor specific feature MND. Axonal spheroids, as tissue, all antineurofilament antibodies. Normal-appearing axons, tissue identified an antiactin antibody, indicating that actin may be absent cytoplasmic domain gives rise spheroids. In summary, we have found posttranslational changes and, particular, are both cells.