Age, Sex and Body Weight Related Echocardiographic Parameters of Clinically Healthy New Zealand White Rabbits

摘要: Background: Echocardiography provides useful additional information on cardiac dimensions including heart wall and dimension of the ventricles, atria conditions. Rabbits have been diagnosed with diseases, an understanding animals’ chamber is vital in assessing diseases’ severity prognoses. Changes due to age related body weight were determined at different animals. The increased incidence congenital cardiovascular anomalies makes it essential establish diagnosis early age. aims this study 1) normal values for commonly used two-dimensional (2D) M-mode parameters using pre anaesthetics 2) evaluate effects age, sex, echocardiographic clinically healthy New Zealand rabbits. Materials, Methods & Results: In we 49 white rabbits (25 male, 24 female) all reared under same A general physical clinical examination complete blood count was performed each animal. Body surface area calculated as BSA= 0.00718 × Height 0.725 Weight 0.425 . sedated midazolam before performed. Echocardiographic a DC 6-Vet ® (Mindray, PRC) ultrasonographic device equipped micro-convex 8 MHz probe. Right parasternal short-axis view, B-mode guided measured. measurements leading-edge-to-leading-edge conventions outlined by American Society Echocardiography. Statistical analyses employed SPSS 19.0 program. Sex had no significant effect measured except case interventricular septum thickness diastole three-month-old increase left ventricular systolic diastolic diameters, E- point septal separation, aortic root three, six, nine-month-old groups indicated persistent anatomic enlargement. However, also discovered that fractional shortening percentage ventricle diameters atrium:aortic  were unrelated weight. Discussion: are important model research, mainly they small relatively inexpensive however large enough allow anatomical physiological experiments. Different ages sizes showed difference despite ejection fraciton, which can be from via echocardiography, another parameter function. Our echocardiograph fraction automatically Teicholz formula. It further observed higher than six This might indicate necessity periodical analysis parameters. Transthoracic echocardiography considered applicable method research growing rabbit animal after appropriate adjustments sex size. These findings give better functional changes investigated will helpful when evaluating data experimental