Ventricular septal defect with aortic valve insufficiency in a New Zealand White rabbit.

作者: Károly Vörös , Frauke Seehusen , Stephan Hungerbühler , Andrea Meyer-Lindenberg , Nina von der Hoeh

DOI: 10.5326/JAAHA-MS-5498

关键词: Pulmonic stenosisVolume overloadAortic valvePulmonary Valve InsufficiencyAnatomyVentricular pressureMedicineHeart murmurCardiologyElectrocardiographyAfterloadInternal medicine

摘要: A heart murmur was detected in a 10 mo old, female New Zealand White rabbit. Auscultation revealed cardiac murmurs both at the left and right hemithorax. Phonocardiography confirmed systolic–diastolic nature of left-sided systolic character right-sided murmur. Electrocardiography showed normal sinus rhythm; tall R waves large T lead II; deep S leads II, III, aVF. Thoracic radiography demonstrated generalized cardiomegaly with prominent pulmonary vasculature. Echocardiography perimembraneous ventricular septal defect aortic insufficiency. Signs biventricular volume overload, relative pulmonic stenosis, valve insufficiency were also seen as consequences defect. Necropsy just below valve, dilated trunk, hypertrophied ventricles, atria, rightward displacement root. Cardiac histopathology cardiomyocy...

参考文章(22)
R W Else, P G Darke, M W Martin, Congestive heart failure with atrial fibrillation in a rabbit. Veterinary Record. ,vol. 121, pp. 570- 571 ,(1987) , 10.1136/VR.121.24.570
Molly Varga, Frances Harcourt-Brown, Textbook of Rabbit Medicine ,(2001)
Daniel J Penny, G Wesley Vick, Ventricular septal defect The Lancet. ,vol. 377, pp. 1103- 1112 ,(2011) , 10.1016/S0140-6736(10)61339-6
M. SHIMIZU, R. TANAKA, K. HOSHI, H. HIRAO, M. KOBAYASHI, S. SHIMAMURA, Y. YAMANE, Surgical correction of ventricular septal defect with aortic regurgitation in a dog Australian Veterinary Journal. ,vol. 84, pp. 117- 121 ,(2006) , 10.1111/J.1751-0813.2006.TB13393.X
L M Valdes-Cruz, S Horowitz, E Mesel, D J Sahn, D C Fisher, D Larson, S J Goldberg, H D Allen, A pulsed Doppler echocardiographic method for calculation of pulmonary and systemic flow: accuracy in a canine model with ventricular septal defect. Circulation. ,vol. 68, pp. 597- 602 ,(1983) , 10.1161/01.CIR.68.3.597
A. Rezakhani, G. Rezaian, Clinical Electrocardiogram of Laboratory White New Zealand Rabbits Journal of Applied Animal Research. ,vol. 7, pp. 63- 68 ,(1995) , 10.1080/09712119.1995.9706051
Wade H. Brown, Louise Pearce, Chester M. Van Allen, ORGAN WEIGHTS OF NORMAL RABBITS Journal of Experimental Medicine. ,vol. 42, pp. 69- 82 ,(1925) , 10.1084/JEM.42.1.69
Jon C. Cook, Catherine F. Jacobson, Feng Gao, Melissa S. Tassinari, Mark E. Hurtt, John M. DeSesso, Analysis of the nonsteroidal anti-inflammatory drug literature for potential developmental toxicity in rats and rabbits. Birth Defects Research Part B-developmental and Reproductive Toxicology. ,vol. 68, pp. 5- 26 ,(2003) , 10.1002/BDRB.10005
S Menahem, J A Johns, S del Torso, T H Goh, A W Venables, Evaluation of aortic valve prolapse in ventricular septal defect. Heart. ,vol. 56, pp. 242- 249 ,(1986) , 10.1136/HRT.56.3.242
A. Tidholm, RETROSPECTIVE STUDY OF CONGENITAL HEART DEFECTS IN 151 DOGS Journal of Small Animal Practice. ,vol. 38, pp. 94- 98 ,(1997) , 10.1111/J.1748-5827.1997.TB03326.X