Urinary Markers of Mast Cell Disease and Their Role in Diagnosis and Management

摘要: A clinical laboratory’s ability to routinely measure products resulting from increased number of mast cells or degranulation by is severely limited. Although measured excessive levels histamine, prostaglandin, and leukotriene metabolites are not currently included among the criteria for diagnosis systemic mastocytosis, quantitate cell mediator can substantiate presence numbers these support mastocytosis. Moreover, when samples obtained contemporaneously acute symptoms activation, above baseline serve corroborate contribution symptoms. Noninvasive urine specimens easily patient at time presenting be used simultaneously pathways. These results subsequently provide evidence-based targets medication treatment prevent symptomatic re-occurrence.