Detectability and structural stability of a liquid fiducial marker in fresh ex vivo pancreas tumour resection specimens on CT and 3T MRI

摘要: To test the detectability of a liquid fiducial marker injected into ex vivo pancreas tumour tissue on magnetic resonance imaging (MRI) and computed tomography (CT). Furthermore, its injection performance using different needle sizes structural stability after fixation in formaldehyde were investigated. Liquid markers with a volume 20–100 µl freshly resected specimens three patients suspected adenocarcinoma. X‑ray guided was performed (18 G, 22 G, 25 G). The scanned MRI CT clinical protocols. segmented by signal thresholding. Marker assessed registered segmentations. volume compared to as a measure backflow. Markers ≥20 µl detected hyperintensity CT. On T1- T2-weighted 3T MRI, ranging from visible hypointensity. Since most non-spherical, poor their differentiation hypointensities caused air cavities or surgical clips only feasible a reference backflow observed when an 18-G needle. A volume decrease 6.6 ± 13.0% 24 h and, exception one instance, no wash-out occurred. liquid pancreatic resection specimen kV hypointensity MRI. marker’s size stable formaldehyde. A marker ≥50 µL is recommended clinically used sequences. In expected improve sphericity due persisting metabolism thereby enhance