Trial 2 in the elevated plus-maze: a different form of fear?

摘要: A factor analysis of the scores from rats given two trials in elevated plus-maze showed that four independent factors emerged. Measures anxiolytic activity on trial 1 (number open arm entries and time spent arms) loaded 1, measures 2 2, measure general closed entries) both 3, a decision (time central square) for 4. The independence anxiety raises possibility state anxiety/fear second is qualitatively different 1. This difference reflected loss action diazepam (2 mg/kg) 2. However, this occurs only when are short (5 min); they longer (10 min) retains efficacy. It concluded during brief acquire specific phobic anxiety, which relatively resistant to benzodiazepines. With exposure form fear extinguishes.