Long-term weekly treatment of colorectal metastatic cancer with fluorouracil and leucovorin: results of a multicentric prospective trial of fluorouracil dosage optimization by pharmacokinetic monitoring in 152 patients.
作者： E Gamelin , M Boisdron-Celle , R Delva , C Regimbeau , P E Cailleux
DOI: 10.1200/JCO.1998.16.4.1470
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摘要: PURPOSEA relationship between fluorouracil (5-FU) dose and response has been previously shown in advanced colorectal cancer. In a previous study with 5-FU stepwise escalation weekly regimen, pharmacokinetic monitoring, we defined therapeutic range for plasma levels: 2,000 to 3,000 microg/L (area under the concentration-time curve at 0 8 hours [AUC0-8], 16 24 mg x h/L). The current investigated intensification individual adjustment multicentric phase II prospective trial.PATIENTS AND METHODSWeekly high-dose was administered by 8-hour infusion 400 mg/m2 leucovorin. initial of (1,300 mg/m2) adapted according levels, reach determined.RESULTSA total 152 patients entered from December 1991 1994: 117 measurable metastatic disease 35 assessable disease. Toxicity mainly diarrhea (39%, 5% grade 3) hand-foot...
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