Diuretic activity of Smilax canariensis, an endemic Canary Island species

摘要: Abstract Ethnopharmacological relevance Smilax canariensis is an endemic species of the Canary Islands, popularly known as “Zarzaparrilla sin espinas”. This has wide use in folk-medicine practice on islands, especially diuretic. So aim our study to evaluate diuretic activity aqueous and a methanol extract this species. Material methods Three infusions doses (250, 500 750 mg/kg) two (100 200 mg/kg) were orally administered laboratory rats. Water excretion rate, pH, density, conductivity, content Na + K measured urine saline-loaded Results rates significantly increased dose-dependent manner by both hot water alcohol extract. The electrolytic was also dose-dependent, although potassium markedly reduced when using compared with that observed for infusion. Conclusions presents notable effect which appeared be related its presence polar organic compounds. present results provide quantitative basis explaining traditional agent Island population.