Correlation Between Violence and Antipsychotic Dosage in Schizophrenia: A Secondary Analysis of The Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE) Dataset.

摘要: Introduction Violent behavior is more common in individuals with schizophrenia, compared to the general population. Studies suggest higher psychotic symptoms are predictive of greater violent behavior. On other hand, behaviors reduced antipsychotic treatment. However, relationship between dosage and violence has not been studied date. Thus, we aimed determine if there exists an association scores whether maximum would be final dosage. We hypothesized that at assessment Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE) correlated corresponding drug severity score Methods end trial was converted into defined daily chlorpromazine equivalents (CPZe). Final sum were analyzed from interviews. Spearman’s rank-order correlation linear regression analyses used analyze standardized dosages. Results The analysis on 952 schizophrenia. There a significant CPZe (p=0.049). Exploratory age ethnicity revealed younger non-white risk engaging activities. Discussion Violence schizophrenia associated poor illness course. Further studies focusing warranted.