Catestatin regulates the colonic mucus layer in inflammatory bowel disease

摘要: Abstract Background The pro-hormone chromogranin A (CgA) and its bioactive cleavage product catestatin (CST) are both associated with inflammatory bowel disease (IBD) dysregulated barrier functions, but their exact role has remained elusive. Here, we demonstrate that CST regulates the colonic mucus layer. Methods levels were measured in feces of IBD patients. layer, goblet cells, immune cell infiltration analyzed by histology electron microscopy colon tissue from patients mice selective deletion CST-coding region CgA gene. Results elevated compared to healthy controls. thickness layer was increased non-affected, not inflamed, regions concomitant production also CST-KO mouse. This phenotype could be reversed bone marrow transplantation wildtype mice. Conclusions produced bone-marrow derived cells reduces intestine. might contribute reduced inflamed Additionally, a biomarker for IBD.