Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets.

摘要: Information processing in the nervous system depends on creation of specific synaptic connections between neurons and targets during development. The homeodomain transcription factor Otx1 is expressed early-generated developing cerebral cortex. Within layer 5, by with subcortical axonal projections to midbrain spinal cord. also precursors these neurons, but localized cytoplasm. Nuclear translocation occurs when 5 enter a period refinement eliminate subset their long-distance projections. mutant mice are defective exuberant projections, suggesting that required for development normal connectivity generation coordinated motor behavior.