(E) Enol ethers from the stereoselective reduction of α-alkoxy-β-ketophosphonates and Wittig type reaction
作者： Wissam Dayoub , Alain Doutheau
DOI: 10.1007/S11426-010-4057-1
关键词:
摘要: When α-alkoxy-β-ketophosphonates, prepared by the Rh(II) mediated insertion reaction of α-diazo-β-ketophosphonates into OH bond primary alcohols, were reduced either NaBH4 in presence CaCl2 or DIBAL, they respectively gave corresponding anti syn stereomeric hydroxyphosphonates with pronounced to complete stereoselectivity. Submitted action potassium tert-butoxyde, isomers led pure (E) enol ethers moderate good yields. Under same conditions a mixture (Z) and rather poor The sequence was applied preparation some allyl-vinyl configuration for vinylic double bond.
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