Changes in thyroid-stimulating and TSH-binding inhibitory activities in a patient who developed hyperthyroidism due to Graves' disease following primary hypothyroidism.
作者： K. KASAGI , J. KONISHI , Y. IIDA , T. MORI , K. TORIZUKA
DOI: 10.1111/J.1365-2265.1986.TB03604.X
关键词:
摘要: A 23-year-old female who developed thyrotoxic Graves' disease following primary hypothyroidism was reported. She presented with symptoms of and slight exophthalmos. After confirmed, she treated T4 in a dose 50 micrograms/d. Two months after delivery, 1 year the initial diagnosis hypothyroidism, hyperthyroidism while taking T4. confirmed by persistent thyrotoxicosis, high 99mTc thyroidal uptake, negative T3 suppressibility detection TSH-receptor antibodies. During hypothyroid phase, TSH-binding inhibitory immunoglobulins (TBII) could not be detected, thyroid stimulating antibodies (TSAb) were positive showing between 5.8 9.0 fold increases amount cAMP produced cultured porcine cells. Her IgG did inhibit TSH-induced increase vitro. When hyperthyroidism, TSAb activity became more potent (31.7 cAMP) TBII (+61.3%).
sci-hub.se 参考文章(23)
Robert Volpé, Robert Ehrlich, George Steiner, Vas V. Row, Graves' disease in pregnancy years after hypothyroidism with recurrent passive-transfer neonatal Graves' disease in offspring The American Journal of Medicine. ,vol. 77, pp. 572- 578 ,(1984) , 10.1016/0002-9343(84)90125-6
KANJI KASAGI, JUNJI KONISHI, YASUHIRO IIDA, KATSUJI IKEKUBO, TORU MORI, KANJI KUMA, KANJI TORIZUKA, A New in Vitro Assay for Human Thyroid Stimulator Using Cultured Thyroid Cells: Effect of Sodium Chloride on Adenosine 3′,5′-Monophosphate Increase* The Journal of Clinical Endocrinology and Metabolism. ,vol. 54, pp. 108- 114 ,(1982) , 10.1210/JCEM-54-1-108
B. Rees Smith, C. R. Rickards, E. Davies Jones, Y. Kajita, P. R. Buckland, F. M. Creagh, R. D. Howells, F. Hashim, A. B. Parkes, V. B. Petersen, The thyrotropin receptor and its role in Graves' disease Journal of Endocrinological Investigation. ,vol. 8, pp. 175- 182 ,(1985) , 10.1007/BF03350678
JUNJI KONISHI, KANJI KASAGI, YASUHIRO IIDA, TADAKO KOUSAKA, TAKASHI MISAKI, KEISUKE ARAI, YASUTAKA TOKUDA, KANJI TORIZUKA, Optimization and clinical assessment of a radioreceptor assay for thyrotropin-binding inhibitor immunoglobulins. Endocrinologia Japonica. ,vol. 34, pp. 13- 20 ,(1987) , 10.1507/ENDOCRJ1954.34.13
TOSHIHIDE YAMAMOTO, Spontaneous Remission from Primary Hypothyroidism Annals of Internal Medicine. ,vol. 88, pp. 808- 809 ,(1978) , 10.7326/0003-4819-88-6-808
Lillian C. Sung, Graves' Hyperthyroidism Archives of Internal Medicine. ,vol. 138, pp. 1009- 1010 ,(1978) , 10.1001/ARCHINTE.1978.03630310085029
James H. Christy, Richard S. Morse, Hypothyroid Graves' disease The American Journal of Medicine. ,vol. 62, pp. 291- 296 ,(1977) , 10.1016/0002-9343(77)90325-4
W IRVINE, SPECTRUM OF THYROID FUNCTION IN PATIENTS REMAINING IN REMISSION AFTER ANTITHYROID DRUG THERAPY FOR THYROTOXICOSIS The Lancet. ,vol. 310, pp. 179- 181 ,(1977) , 10.1016/S0140-6736(77)90192-1
JUNJI KONISHI, YASUHIRO IIDA, KEIGO ENDO, TAKASHI MISAKI, YACHIYO NOHARA, NOBUO MATSUURA, TORU MORI, KANJI TORIZUKA, Inhibition of thyrotropin-induced adenosine 3'5'-monophosphate increase by immunoglobulins from patients with primary myxedema. The Journal of Clinical Endocrinology and Metabolism. ,vol. 57, pp. 544- 549 ,(1983) , 10.1210/JCEM-57-3-544
KANJI KASAGI, JUNJI KONISHI, KEISUKE ARAI, TAKASHI MISAKI, YASUHIRO IIDA, KEIGO ENDO, KANJI TORIZUKA, A sensitive and practical assay for thyroid-stimulating antibodies using crude immunoglobulin fractions precipitated with polyethylene glycol The Journal of Clinical Endocrinology and Metabolism. ,vol. 62, pp. 855- 862 ,(1986) , 10.1210/JCEM-62-5-855