Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols.
作者： Y.C. O'Callaghan , J.A. Woods , N.M. O'Brien
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摘要: The cytotoxicity of the oxysterols 25-hydroxycholesterol, 7β-hydroxycholesterol, cholesterol-5α,6α-epoxide, cholesterol-5β,6β-epoxide, 19-hydroxycholesterol and 7-ketocholesterol was examined in U937 cells, a human monocytic blood cell line. 7β-Hydroxycholesterol, 7-ketocholesterol, at 30 μmol/L concentration, were found to be cytotoxic this line mode death by apoptosis. 25-Hydroxycholesterol, cholesterol-5α,6α-epoxide (30 μmol/L) did not induce apoptosis Since it has been suggested that generation an oxidative stress may occur early stages apoptotic process, glutathione concentration activity superoxide dismutase also measured oxysterol-treated cells. 7β-Hydroxycholesterol shown increase decrease concentration. However, cholesterol-5β,6β-epoxide which apoptosis, affect or Therefore, oxysterol-induced dependent on stress.
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