Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation.
作者： Y.W. Cheng , J.J. Kang , Y.L. Shih , Y.L. Lo , C.F. Wang
DOI: 10.1016/J.FCT.2005.01.007
关键词:
摘要: The mutagenicity of oxysterols, cholesterol-3β,5α,6β-triol (α-Triol), 7-keto-cholesterol (7-Keto) and cholesterol-5α,6α-epoxide (α-Epox) were examined by the Ames method chromosome aberration test in this study. Only α-Triol concentration-dependently caused an increase bacterial revertants absence metabolic activating enzymes (S9), but not 7-keto α-Epox. mutagenic effect was reduced addition S9. On other hand, although significantly induced CHO-K1 cells with without However, S9 degree abnormal structure compared to mix. Catalase superoxide dismutase (SOD) inhibited Salmonella typhimurium frequency CHO cells, suggesting that reactive oxygen species (ROS) might be involved genotoxic α-Triol. Treatment increased ROS production which could attenuated catalase SOD. Results study suggested, for first time α-Triol, causes ROS-dependent manner.
elsevier.com
sci-hub.se 参考文章(24)
C.-Y. Tai, Y.C. Chen, B.H. Chen, Analysis, formation and inhibition of cholesterol oxidation products in foods: an overview (part II). Journal of Food and Drug Analysis. ,vol. 8, pp. 1- 15 ,(2020) , 10.38212/2224-6614.2860
Y.C. O'Callaghan, J.A. Woods, N.M. O'Brien, Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. Cell Biology and Toxicology. ,vol. 17, pp. 127- 137 ,(2001) , 10.1023/A:1010914306375
Gerard Lizard, Serge Gueldry, Olivier Sordet, Serge Monier, Anne Athias, Carole Miguet, Ginette Bessede, Stephanie Lemaire, Eric Solary, Philippe Gambert, Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production The FASEB Journal. ,vol. 12, pp. 1651- 1663 ,(1998) , 10.1096/FASEBJ.12.15.1651
H.A. EMANUEL, C.A. HASSEL, P.B. ADDIS, S.D. BERGMANN, J.H. ZAVORAL, Plasma Cholesterol Oxidation Products (Oxysterols) in Human Subjects Fed a Meal Rich in Oxysterols Journal of Food Science. ,vol. 56, pp. 843- 847 ,(1991) , 10.1111/J.1365-2621.1991.TB05396.X
Louis H. Krut, Joseph W. Yang, Gustav Schonfeld, Richard E. Ostlund, Jr, The Effect of Oxidizing Cholesterol on Gastrointestinal Absorption, Plasma Clearance, Tissue Distribution, and Processing by Endothelial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 17, pp. 778- 785 ,(1997) , 10.1161/01.ATV.17.4.778
J. T. Chien, H. C. Wang, B. H. Chen, Kinetic Model of the Cholesterol Oxidation during Heating Journal of Agricultural and Food Chemistry. ,vol. 46, pp. 2572- 2577 ,(1998) , 10.1021/JF970788D
Leland L. Smith, Vera B. Smart, N.M. Made Gowda, Mutagenic sterol hydroperoxides Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. ,vol. 161, pp. 39- 48 ,(1986) , 10.1016/0027-5107(86)90098-9
Edward J. Parish, Sarawanee C. Parish, Shengrong Li, Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by side-chain oxysterols and their derivatives. Critical Reviews in Biochemistry and Molecular Biology. ,vol. 34, pp. 265- 272 ,(1999) , 10.1080/10409239991209291
Dorothy M. Maron, Bruce N. Ames, REVISED METHODS FOR THE SALMONELLA MUTAGENICITY TEST Mutation Research. ,vol. 113, pp. 173- 215 ,(1983) , 10.1016/0165-1161(83)90010-9
A. Matsuoka, M. Hayashi, M. Ishidates, Chromosomal aberration tests on 29 chemicals combined with S9 mix in vitro. Mutation Research\/genetic Toxicology. ,vol. 66, pp. 277- 290 ,(1979) , 10.1016/0165-1218(79)90089-2