ROS-mediated oligomerization of VDAC2 is associated with quinocetone-induced apoptotic cell death.
作者： Xiayun Yang , Shusheng Tang , Daowen Li , Bin Li , Xilong Xiao
DOI: 10.1016/J.TIV.2017.12.005
关键词:
摘要: Quinocetone (QCT) has been approved and widely used as an animal feed additive in China since 2003. However, investigations indicate that QCT shows potential toxicity both vitro vivo. Although voltage dependent anion channel 1 (VDAC1) involved regulating QCT-induced apoptotic cell death established, the role of 2 (VDAC2) remains unclear. In this study, we showed was coupled to VDAC2 oligomerization. Moreover, VDAC inhibitor 4, 4'-diisothiocyano stilbene-2, 2'-disulfonic acid (DIDS) alleviated Meanwhile, overexpression aggravated addition, caspase Z-VAD-FMK reactive oxidative species (ROS) scavenger N-acetyl-l-cysteine (NAC) apparently blocked Finally, N-terminal truncated attenuated oligomerization but had no influence on its localization mitochondria when comparing full length VDAC2. Taken together, our results reveal ROS-mediated is associated with death. The region required for
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