Simvastatin, dosage and delivery system for supporting bone regeneration, an update review

摘要: Abstract Objective The purpose of this review is to discuss the dosage, duration and carrier for simvastatin, summarize effects topical application directly or indirectly stimulating bone regeneration. Methods We have searched in Pubmed using keywords, dose response, regeneration, controlled-release delivery system. This search was complemented with a manual relevant articles cited among selected papers. written English published last 10 years. were revised depth, summarized. Results High simvastatin increases formation resorption, while low decreases furthermore it reported that high systemic administration will raise risk liver failure, kidney disease, other side effects. Local can bypass hepatic degradation statins achieve therapeutic concentrations avoid choice appropriate depend on release kinetics determined be best osteogenesis. Conclusion from carriers appears an attractive solution problem maintaining doses treat severe defects minimize undesired Locally delivered increase accelerate healing process bony defect. Another advantage local system stimulate new dose-dependent manner. Further evidence-based studies required determine promote