Histaminuria in Urticaria Pigmentosa

摘要: Urticaria pigmentosa, a form of mastocytosis, is an uncommon cutaneous disease characterized by dermal infiltration mast cells. Clinically, the eruption consists brownish macules, papules, or vesicles; nodules are rarely present. Urtication lesions following mild trauma pathognomonic sign. Recently, systemic involving mast-cell infiltrations bone, bone marrow, liver, spleen, and lymph nodes have been reported. This has designated "systemic mastocytosis,'' as opposed to ``mastocytosis cutis'' simple urticaria pigmentosa. In addition, tumorlike infiltrates may occur solitary nodules, particularly in children; this mastocytosis termed "isolated mastocytoma.'' The found contain large amounts histamine, Pernow Waldenstrom1have reported increased urinary excretion histamine patients with On other hand, tissue analysis revealed only trace serotonin, Davis, Lawler, Higdon2reported