Prognostic factors differ by tumor stage for small cell lung cancer: a pooled analysis of North Central Cancer Treatment Group trials

摘要: BACKGROUND: An analysis of 14 small cell lung cancer (SCLC) trials was performed to improve the current understanding potential prognostic factors for overall survival (OS) and progression-free (PFS) in groups patients with limited-stage disease SCLC (LD-SCLC) extensive-stage (ED-SCLC) separately. METHODS: Data on 688 LD-SCLC 910 ED-SCLC were included. Clinical laboratory tested their significance using Cox regression models that stratified by protocol. Recursive partitioning amalgamation (RPA) analyses used identify subgroups. RESULTS: Poorer performance status (PS) led worse OS PFS group but not group. The impact PS strong men weak women (interaction P value <.012 PFS). Other negative included increased age age, men, number metastatic sites at baseline, creatinine levels In ED-SCLC, RPA identified 5 subgroups different prognosis based baseline PS, levels, sex, sites. CONCLUSIONS: The pooled as important addition well established PS. There a significant interaction between sex within group, suggesting is highly has no women. Within only factors. confirmed many these findings. Cancer 2009. © 2009 American Society.