Pre-mir-27a rs895819 polymorphism and cancer risk: a meta-analysis
作者： Shanliang Zhong , Zhiyuan Chen , Jinjin Xu , Wenjing Li , Jianhua Zhao
DOI: 10.1007/S11033-012-2392-3
关键词:
摘要: Aberrant expression of miRNAs plays critical roles in cancer development. Single nucleotide polymorphism (SNP) miRNA precursors may affect levels. An important SNP the pre-mir-27a with a A to G change (rs895819) was identified. Several original studies have explored role this risk, but results these remain conflicting rather than conclusive. Therefore, we performed meta-analysis published derive more precise estimation association between rs895819 and risk. In meta-analysis, total 6 case–control (including 3,255 cases 4,181 controls) were analyzed. The overall did not suggest any associations susceptibility. However, an decreased risk observed subgroup breast patients (G vs A: OR = 0.90, 95 % CI = 0.83 ~ 0.97; P heterogeneity = 0.75) or Caucasian race CI = 0.83 ~ 0.97, = 0.78, I 2 = 0; AG AA: OR = 0.84, CI = 0.75 ~ 0.94, = 0.35, 2 = 3.7 %; GG+AG OR = 0.85, CI = 0.76 ~ 0.94, = 0.48, 2 = 0). findings that some relation susceptibility development Caucasian.
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