Melatonin regulates glucocorticoid receptor: an answer to its antiapoptotic action in thymus
作者： Rosa María Sainz , Juan Carlos Mayo , Russel J. Reiter , Isaac Antolín , Manuel M. Esteban
DOI: 10.1096/FASEBJ.13.12.1547
关键词:
摘要: We have previouslyreported that low doses of melatonin inhibit apoptosis in both dexamethasone-treated cultured thymocytes (standard model for the study apoptosis) and intact thymus. Here we elucidate mechanism by which this agent protects from cell death induced glucocorticoids. Our results demonstrate an effect on mRNA antioxidant enzymes thymocytes, also showing unexpected regulation dexamethasone these mRNA. Both general machinery a possible expression related genes bcl-2 p53 are shown not to be involved. found down-regulate glucocorticoid receptor (glucocorticoids up-regulate their own receptor). The decrease levels IM-9 cells (where glucocorticoids it) demonstrates actually down-regulates receptor. These findings allow us p...
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