Diet in the Pathogenesis and Treatment of Inflammatory Bowel Diseases

摘要: Some of the most common symptoms inflammatory bowel diseases (IBD, which include ulcerative colitis and Crohn's disease) are abdominal pain, diarrhea, weight loss. It is therefore not surprising that clinicians patients have wondered whether dietary patterns influence onset or course IBD. The question what to eat among commonly asked by patients, difficult answer for clinicians. There substantial variations in behaviors recommendations them, although do routinely endorse specific diets with Dietary clinical trials been limited their inability a placebo control, contamination study groups, inclusion receiving medical therapies. Additional challenges accuracy information on intake, complex interactions between foods consumed, differences food metabolism individuals. We review roles diet etiology management IBD based plausible mechanisms evidence. Researchers learned much about effects mucosal immune system, epithelial function, intestinal microbiome; these findings could significant practical implications. Controlled studies enteral nutrition observations made from exclusion shown components whole can deleterious Additionally, animal models suggested certain nutrients reduce inflammation. In future, engineered restrict but supplement beneficial be used modify luminal environment IBD; might alone combination immunosuppressive agents, as salvage therapy who respond lose responsiveness Stricter required induce remission, more sustainable maintain long-term remission.