Methylation markers for colorectal cancer
作者： Louis Vermeulen , Jan Paul Medema , Felipe De Sousa E Melo
DOI:
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摘要: The present invention provides a method of determining the risk developing metastasis and/or tumor relapse in colorectal cancer patient, comprising steps providing biological sample said and methylation status expression level gene selected from group consisting LGR5, APCDD1, ΑΧIΝ2, DKK1, ASCL2, an increased relapse, under condition that hypermethylation is determined ΑΧΓΝ2, ASCL2.
lens.org 参考文章(72)
Kenneth B. Beckman, Robert D. Larsen, Kathleen Y. Lee, Asymmetric pcr with nuclease-free polymerase or nuclease-resistant molecular beacons ,(2002)
Tamotsu Sugai, Wataru Habano, Yu-Fei Jiao, Mitsunori Tsukahara, Yuichiro Takeda, Koki Otsuka, Shin-ichi Nakamura, Analysis of Molecular Alterations in Left- and Right-Sided Colorectal Carcinomas Reveals Distinct Pathways of Carcinogenesis: Proposal for New Molecular Profile of Colorectal Carcinomas The Journal of Molecular Diagnostics. ,vol. 8, pp. 193- 201 ,(2006) , 10.2353/JMOLDX.2006.050052
Axel Wein, Ralph Markus Wirtz, Marc Munnes, Wolfgang Michael Bruckl, Tumor marker for use in the diagnosis of colorectal carcinomas and/or metastases originating therefrom ,(2005)
Gary Siuzdak, Mass spectrometry for biotechnology ,(1996)
David Lane, Ed Harlow, Antibodies: A Laboratory Manual ,(1988)
Shota Tanaka, Mika Hosokawa, Kumiko Ueda, Seigo Iwakawa, Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells Biological & Pharmaceutical Bulletin. ,vol. 38, pp. 1272- 1279 ,(2015) , 10.1248/BPB.B15-00129
Stephen B. Baylin, James G. Herman, Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids ,(1997)
Jean Paul Thiery, Hervé Acloque, Ruby Y.J. Huang, M. Angela Nieto, Epithelial-Mesenchymal Transitions in Development and Disease Cell. ,vol. 139, pp. 871- 890 ,(2009) , 10.1016/J.CELL.2009.11.007
P. J. Morin, Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. ,vol. 275, pp. 1787- 1790 ,(1997) , 10.1126/SCIENCE.275.5307.1787
K Koinuma, Y Yamashita, W Liu, H Hatanaka, K Kurashina, T Wada, S Takada, R Kaneda, Y L Choi, S-I Fujiwara, Y Miyakura, H Nagai, H Mano, Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability. Oncogene. ,vol. 25, pp. 139- 146 ,(2006) , 10.1038/SJ.ONC.1209009