A novel aliphatic 18F-labeled probe for PET imaging of melanoma.
作者： Hongguang Liu , Shuanglong Liu , Zheng Miao , Han Jiang , Zixin Deng
DOI: 10.1021/MP400225S
关键词:
摘要: Radiofluorinated benzamide and nicotinamide analogues are promising molecular probes for the positron emission tomography (PET) imaging of melanoma. Compounds containing aromatic (benzene or pyridine) N,N-diethylethylenediamine groups have been successfully used development melanin targeted PET single-photon computed (SPECT) agents The objective this study was to determine feasibility using aliphatic compounds as a platform new generation melanoma detection. An precursor directly coupled radiofluorination synthon, p-nitrophenyl 2-18F-fluoropropionate (18F-NFP), produce probe N-(2-(diethylamino)ethyl)-2-18F-fluoropropanamide (18F-FPDA). melanoma-targeting ability 18F-FPDA further evaluated both in vitro vivo through cell uptake assays, biodistribution studies, small animal C57BL/6 mice bearing B16F10...
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