MRI Reporter Genes for Noninvasive Molecular Imaging

摘要: Magnetic resonance imaging (MRI) is one of the most important technologies used in clinical diagnosis. Reporter genes for MRI can be applied to accurately track delivery cell therapy, evaluate therapy effect gene delivery, and monitor tissue/cell-specific microenvironments. Commonly reporter usually include encoding enzyme (e.g., tyrosinase β-galactosidase), receptor on cells transferrin receptor), endogenous ferritin gene). However, low sensitivity limits application gene-based multimodal strategies are common including optical radionuclide imaging. These significantly improve diagnostic efficiency accelerate development new therapies.