Engineering strategies to mimic the glioblastoma microenvironment

摘要: Glioblastoma multiforme (GBM) is the most common and deadly brain tumor, with a mean survival time of only 21months. Despite dramatic improvements in our understanding GBM fueled by recent revolutions molecular systems biology, treatment advances for have progressed inadequately slowly, which due part to wide cellular heterogeneity both across tumors within single tumor. Thus, there increasing clinical interest targeting cell-extrinsic factors as way slowing or halting progression GBM. These factors, collectively termed microenvironment, include extracellular matrix, blood vessels, stromal cells that surround tumor cells, all associated soluble scaffold-bound signals. In this review, we will first describe regulation these microenvironmental factors. Next, discuss various vitro approaches been exploited recapitulate model microenvironment vitro. We conclude identifying future challenges opportunities field, including development platforms amenable high-throughput discovery screening. anticipate ongoing efforts prove be valuable enabling tools accelerating foundations next-generation screening may serve conceptual bridge between traditional reductionist animal studies.