Modified coagulation factor viia with extended half-life
作者： Ulrich Kronthaler , Wilfried Wormsbächer , Uwe Liebing , Thomas Weimer , Stefan Schulte
DOI:
关键词:
摘要: The present invention relates to the fields of Factor VII (FVII) and VIIa (FVIIa) albumin linked polypeptides. More specifically, cDNA sequences coding for human derivatives genetically fused a serum which may be by oligonucleotides code intervening peptidic linkers such encoded exhibiting improved stability extended functional plasma half-life, recombinant expression vectors containing sequences, host cells transformed with vectors, polypeptides do have biological activities unmodified wild type protein but having prolonged shelf-life processes manufacture proteins their derivatives. also covers transfer vector use in gene therapy, comprises modified DNA sequences.
glgoo.top参考文章(210)
Tom Hollon, HGS targets patent-expiring drugs. Nature Biotechnology. ,vol. 18, pp. 1238- 1239 ,(2000) , 10.1038/82333
M Ragni, G White, A Shapiro, J Goodfellow, P Garzone, S Courter, K Tubridy, Clinical evaluation of recombinant factor IX. Seminars in Hematology. ,vol. 35, pp. 33- 38 ,(1998)
Rodger L. Bick, Gene Murano, Physiology of Hemostasis Clinics in Laboratory Medicine. ,vol. 14, pp. 677- 707 ,(1994) , 10.1016/S0272-2712(18)30352-4
U Seligsohn, B Osterud, SI Rapaport, Coupled amidolytic assay for factor VII: its use with a clotting assay to determine the activity state of factor VII Blood. ,vol. 52, pp. 978- 988 ,(1978) , 10.1182/BLOOD.V52.5.978.978
JH Morrissey, BG Macik, PF Neuenschwander, PC Comp, Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation Blood. ,vol. 81, pp. 734- 744 ,(1993) , 10.1182/BLOOD.V81.3.734.734
Russell F Doolittle, The evolution of vertebrate blood coagulation : a case of yin and yang Thrombosis and Haemostasis. ,vol. 70, pp. 24- 28 ,(1993) , 10.1055/S-0038-1646154
Higashi, Molecular interaction between factor VII and tissue factor International Journal of Hematology. ,vol. 67, pp. 229- 241 ,(1998) , 10.1016/S0925-5710(98)00018-8
Brian D. Follstad, Improvement of cell culture performance by inhibitors of pyruvate dehydrogenase kinase ,(2001)
Gilbert C White, Aime Beebe, Brenda Nielsen, Recombinant factor IX. Thrombosis and Haemostasis. ,vol. 78, pp. 261- 265 ,(1997) , 10.1055/S-0038-1657536
Anna C. Jelmberg, Catherine E. Lofton-Day, Si Lok, Darrell C. Conklin, Stephen R. Jaspers, Robyn L Adams, Testis-specific insulin homolog polypeptides ,(1997)