Blood coagulation factor ⅶ and ⅶa derivatives, conjugates and complexes comprising the same, and use thereof
作者： Sung Hwan Hong , Dae Jin Kim , Byung Sun Lee , Sung Youb Jung , Yong Ho Huh
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摘要: The present invention relates to a blood coagulation factor Ⅶ derivative, Ⅶa FacⅦ and FacⅦa conjugates each prepared by linking polymer capable of extending the half-life complexes carrier conjugate, genes encoding derivatives, expression vectors comprising genes, transformants introduced with vectors, method for preparing derivatives using transformants, conjugate complex, complex method, pharmaceutical composition prevention or treatment hemophilia as an active ingredient, ingredient. Further, preventing treating promoting coagulation, administering subject therapeutically effective amount composition. derivative is able bind improving while maintaining activity FacⅦa, they can be widely used in development prophylactic therapeutic agent hemophilia.
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