Physical demands at work, physical fitness, and 30-year ischaemic heart disease and all-cause mortality in the Copenhagen Male Study

摘要: Objective No previous long-term prospective studies have examined if workers with low cardiorespiratory fitness an increased risk of cardiovascular mortality due to high physical work demands. We tested this hypothesis. Method carried out a 30-year follow-up the Copenhagen Male Study 5249 employed men aged 40–59 years. excluded from 274 history myocardial infarction, prevalent symptoms angina pectoris, or intermittent claudication. estimated [maximal oxygen consumption (VO 2 Max)] using Astrand cycling test and determined demands two self-reported questions. Results In Study, 587 (11.9%) died ischaemic heart disease (IHD). Using as reference group, Cox analyses – adjusted for age, blood pressure, smoking, alcohol consumption, body mass index, diabetes, hypertension showed that were associated IHD in least fit [VO Max range 15–26, N=892, hazard ratio (HR) 2.04, 95% confidence interval (95% CI) 1.20–3.49] moderately 27–38, N=3037, HR 1.75, CI 1.24–2.46), but not among most 39–78, N=1014, 1.08, 0.52–2.17). found similar, although slightly weaker, relationship respect all-cause mortality. Conclusions The hypothesis was supported. Men medium exposed Ours observations suggest that, demands, being physically protects against adverse effects.