Aging and TOR: Interwoven in the fabric of life
作者： Zelton Dave Sharp
DOI: 10.1007/S00018-010-0542-0
关键词:
摘要: Longstanding results with calorie and growth factor restriction plus recent the first interventional drug suggest that retarding pace of aging to improve quality life older people is at hand. The biological system targeted by these approaches target rapamycin (TOR), which central for cellular responses a variety stimuli including stressors, factors, nutrients energy states. That life-extending response reducing its activity highly conserved from yeast mammals consistent evolution as strategy preserve reproductive potential young cells animals.
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