Epigenetics in Cardiovascular Biology

摘要: Correct gene expression is a conditio sine qua for proper development of the heart; cardiovascular disease often due to deregulation expression. Epigenetics major mechanism controlling regulation in eukaryotic cells and consists modulation patterns without modifying actual DNA sequence. The alteration epigenetic mechanisms has been found be involved etiology several diseases, such as cancer, diabetes, neuronal disorders (e.g. Rett syndrome Parkinson’s disease); epigenetics also linked heart disease. In particular, histone acetylation chromatin remodeling are two important both activation cardiac-specific genes repression non-cardiac ones during development, re-programming that underlies cardiac hypertrophy. This chapter gives an overview role pathologies – failure atherosclerosis.