Challenges and Opportunities in Modeling Pancreatic Cancer.

摘要: The ability to faithfully model complex processes lies at the heart of experimental biology. Although a reductionist approach necessarily reduces this complexity, it is nevertheless required for untangling contributions and interactions various system components. It has long been appreciated that cancer process involves positive negative between tumor cells, normal host tissue, associated cells microenvironment. However, accurate models studying these in vitro have remained elusive. We seek generate mouse human pancreatic are relevant disease biology useful elucidating poorly understood facets deadly disease. model, manipulate, predict therapeutic response an individual's outside their body represents promise precision medicine. Therefore, patient-specific allow identification new biomarkers novel treatment modalities rapid translation clinic. In perspective we will discuss recent advances modeling vitro, discoveries enabled, future challenges opportunities awaiting further investigation.