Advanced or metastatic gastrointestinal stromal tumors: Systemic treatment options

摘要: Gastrointestinal stromal tumor (GIST), the most common sarcoma arising in gastrointestinal tract, typically expresses tyrosine-kinase receptor, C-KIT, and contains activating mutation c-kit or platelet-derived growth factor receptor (pdgfr) gene. Recently, development of small molecules that inhibit kinase activity mutant C-KIT PDGFR proteins has radically changed treatment prognosis patients diagnosed with advanced GIST as this molecularly ‘‘targeted’’ therapy demonstrated remarkable high-level disease. J. Surg. Oncol. 2011;104:888–895. 2011 Wiley Periodicals, Inc.