Concentration differences in isoforms of transferrin in blood from alcoholics during abuse and abstinence.

摘要: Abstract At least five different forms of iron-saturated transferrin (Tf) from blood plasma can be separated by isoelectric focusing. These differ in the carbohydrate parts, especially amount sialic acid. The increased relative concentration form with point 5.7 (Tf ) has been shown to a good indicator for liver effects caused alcohol abuse However, alcoholics during abstinence newly formed higher acid content than most already present blood. This indicates that elevated Tf low content, found is not due defect at sialylation, but probably an impaired uptake acid-deficient hepatocytes membrane dysfunction.