Lipopolysaccharide binding protein derivatives
作者： Patrick W. Trown , Héle{overscore }e Gazzano-Santoro , Georgia Theofan
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摘要: Disclosed are novel biologically active lipopolysaccharide binding protein (LBP) derivatives including LBP derivative hybrid proteins which characterized by the ability to bind and neutralize LPS lack CD14-mediated immunostimulatory properties of holo-LBP.
lens.org 参考文章(57)
Richard J. Ulevitch, Peter S. Tobias, Acute phase protein modulating endotoxic activity of lipopolysaccharides, compositions and methods ,(1986)
R. J. Ulevitch, D. C. Morrison, The effects of bacterial endotoxins on host mediation systems. A review. American Journal of Pathology. ,vol. 93, pp. 526- 618 ,(1978)
R.G. Little, D.N. Kelner, E. Lim, D.J. Burke, P.J. Conlon, Functional domains of recombinant bactericidal/permeability increasing protein (rBPI23) Journal of Biological Chemistry. ,vol. 269, pp. 1865- 1872 ,(1994) , 10.1016/S0021-9258(17)42107-7
R P Schleimer, B K Rutledge, Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin 1, endotoxin, and tumor-promoting phorbol diesters. Journal of Immunology. ,vol. 136, pp. 649- 654 ,(1986)
J Weiss, P Elsbach, B A Mannion, E S Kalatzis, Preferential binding of the neutrophil cytoplasmic granule-derived bactericidal/permeability increasing protein to target bacteria. Implications and use as a means of purification. Journal of Immunology. ,vol. 142, pp. 2807- 2812 ,(1989)
K Mészáros, J B Parent, I Chan, C Birr, H Kasler, S F Carroll, G Theofan, A H Horwitz, P S Liu, R E Williams, An amino-terminal fragment of human lipopolysaccharide-binding protein retains lipid A binding but not CD14-stimulatory activity Journal of Immunology. ,vol. 152, pp. 3623- 3629 ,(1994)
Richard Ulevitch, Peter Tobias, John C. Mathison, Samuel D. Wright, Methods and compositions for ameliorating the symptoms of sepsis ,(1990)
J. Han, J.C. Mathison, R.J. Ulevitch, P.S. Tobias, Lipopolysaccharide (LPS) binding protein, truncated at Ile-197, binds LPS but does not transfer LPS to CD14. Journal of Biological Chemistry. ,vol. 269, pp. 8172- 8175 ,(1994) , 10.1016/S0021-9258(17)37176-4
Randal W. Scott, Marian N. Marra, Treatment of endotoxin-associated shock and prevention thereof using a BPI protein ,(1992)
J M Harlan, H D Ochs, P G Beatty, K A Stanness, T H Pohlman, An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism. Journal of Immunology. ,vol. 136, pp. 4548- 4553 ,(1986)