Characterization and detection of sequences associated with autoimmune diseases
作者： Glenn T. Horn , Henry A. Erlich
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摘要: DNA sequences and corresponding amino acid from the HLA class II beta region of human genome that are associated with insulin-dependent diabetes mellitus (IDDM) Pemphigus vulgaris (PV) have been identified. Specifically, marker which detect either directly or indirectly identity codon encoding for at position 57 DQ-beta protein sequence disclosed as well DR-beta region. These may be used to generate hybridization probes antibodies assays a person's susceptibility autoimmune diseases, such IDDM PV. Such peptides encoded by said can therapeutically prophylactically.
google.nl 参考文章(53)
Gerald T. Nepom, Diagnostic probe for rheumatoid arthritis predisposition ,(1987)
Robert C. Giles, J. Donald Capra, Structure, function, and genetics of human class II molecules. Advances in Immunology. ,vol. 37, pp. 1- 71 ,(1985) , 10.1016/S0065-2776(08)60337-5
J Srinivasappa, J Saegusa, B S Prabhakar, M K Gentry, M J Buchmeier, T J Wiktor, H Koprowski, M B Oldstone, A L Notkins, Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues. Journal of Virology. ,vol. 57, pp. 397- 401 ,(1986) , 10.1128/JVI.57.1.397-401.1986
H L Nakhasi, B C Meyer, T Y Liu, Rubella virus cDNA. Sequence and expression of E1 envelope protein. Journal of Biological Chemistry. ,vol. 261, pp. 16616- 16621 ,(1986) , 10.1016/S0021-9258(18)66611-6
Michael B. A. Oldstone, Abner Louis Notkins, Concepts in viral pathogenesis ,(1984)
Henry Anthony Erlich, Kary Banks Mullis, Glenn Thomas Horn, Randall Keichi Saiki, Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids and kits therefor ,(1987)
G. Angelini, C. de Preval, J. Gorski, B. Mach, High-resolution analysis of the human HLA-DR polymorphism by hybridization with sequence-specific oligonucleotide probes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 4489- 4493 ,(1986) , 10.1073/PNAS.83.12.4489
David Owerbach, Bruno Hägglöf, Åke Lernmark, Gösta Holmgren, Susceptibility to Insulin-dependent Diabetes Defined by Restriction Enzyme Polymorphism of HLA-D Region Genomic DNA Diabetes. ,vol. 33, pp. 958- 965 ,(1984) , 10.2337/DIAB.33.10.958
H.J Bodansky, B.M Dean, G.F Bottazzo, P.J Grant, J Mcnally, M.H Hambling, J.K Wales, Islet-cell antibodies and insulin autoantibodies in association with common viral infections. The Lancet. ,vol. 328, pp. 1351- 1353 ,(1986) , 10.1016/S0140-6736(86)92003-9