Studies on Absorption and Excretion of Drugs. III. Kinetics of Penetration of Sulfonamides through the Intestinal Barrier in Vitro

摘要: 1. The penetration ofsulfonamides through the rat small intestine was investigated from physicochemical standpoint in vitro.2. Theoretical equations for mechanism of sulfathiazole were derived assumption that it penetrates intestinal barrier its three forms at respective rates.3. From data obtained, permeability coefficients undissociated, alkaline and acid sulfathiazole, P1, P2, P3 statistically determined. estimated values 0.00064, 0.00979, 0.00132 (cc./cm./min.), respectively.4. experiment equilibrium state attempted order to examine validity theoretical equation. Satisfactory results are obtained P1 P3, but not P2.5. rates fivesulfonamides compared same pH value. following order: sulfisomezole>sulfamethoxypyridazine