Physicochemical and in vitro cation release relevance of therapeutic muds “maturation”

摘要: Abstract Therapeutic muds are used in the treatment of illnesses locomotor apparatus, including osteoarthritis and rheumatologic diseases. The mechanisms action this therapy a matter discussion, mainly for different traditions pelotherapy centers. Heat plays fundamental role beneficial effects thermal mud together with possible transfer across skin barrier chemical elements presented mud. Preparation procedures therapeutic have been orally transmitted since ancient times, being accepted that require “maturation” process to achieve desired results. Pharmaceutical research maturation is crucial ascertain changes induced by operation properties muds. In particular, it necessary verify associated physical and/or sustain traditional use preparation Two clay samples were prepare mineral medicinal water from spring Graena (Cortes y Graena, Granada, Spain). Muds matured three months characterized over time those considered relevant view their topical administration (rheological particle size distribution) (composition, pH, cation exchange capacity, amount cations released). Maturation studied did not induce alteration minerals, even if decrease amplitude distribution, pH disappearance thixotropic behavior observed. increased release but improve properties. case, thermophysical activity maturation. Conversely, released muds, appearing as ionic content these systems. could therefore explain differential compared other thermotherapeutic agents.