Use of crystalline mesoporous silica based materials for the fixation and controlled release of drugs and pharmaceutical composition comprising the same

作者: Jan Van Humbeeck , Johan Adriaan Martens , Alexander Jan Maria Herman Eugeen Aerts , Guy Van Den Mooter , Christine Eva Antonia Kirschhock

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摘要: This invention provides the use of a substantially ordered mesoporous oxide based material for fixation or immobilisation biologically active species, especially in form pharmaceutical composition, wherein said has one more levels porosity and structural order, provided that when single level order it is obtained absence an alpha-tocopherol polyethylene glycol ester templating biomolecule.

参考文章(5)
Jun Liu, Lei Chenghong, Eric J. Ackerman, Proteins in a porous support ,(2002)
M. Vallet-Regi, A. Rámila, R. P. del Real, J. Pérez-Pariente, A New Property of MCM-41:  Drug Delivery System Chemistry of Materials. ,vol. 13, pp. 308- 311 ,(2001) , 10.1021/CM0011559
S.P.B. Kremer, C.E.A. Kirschhock, A. Aerts, K. Villani, J.A. Martens, O.I. Lebedev, G. Van Tendeloo, Tiling silicalite-1 nanoslabs into 3D mosaics Advanced Materials. ,vol. 15, pp. 1705- 1707 ,(2003) , 10.1002/ADMA.200305266