Shared heritability and functional enrichment across six solid cancers
作者： Xia Jiang , Hilary K Finucane , Fredrick R Schumacher , Stephanie L Schmit , Jonathan P Tyrer
DOI: 10.1038/S41467-018-08054-4
关键词:
摘要: Quantifying the genetic correlation between cancers can provide important insights into mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six types based on a total of 296,215 cases and 301,319 controls European ancestry, here we estimate pair-wise correlations breast, colorectal, head/neck, lung, ovary prostate cancer, 38 other diseases. We observed statistically significant lung head/neck (rg = 0.57, p = 4.6 × 10−8), breast ovarian (rg = 0.24, p = 7 × 10−5), (rg = 0.18, p =1.5 × 10−6) colorectal (rg = 0.15, p = 1.1 × 10−4). also found that multiple are genetically correlated with non-cancer traits including smoking, psychiatric diseases metabolic characteristics. Functional enrichment analysis revealed excess contribution conserved regulatory regions to heritability. Our comprehensive cross-cancer heritability suggests solid tumors arising tissues share in part common germline basis.
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