A Randomized Comparison of Anthropomorphic Changes With Preferred and Alternative Efavirenz-Based Antiretroviral Regimens in Diverse Multinational Settings

摘要: Background.  Existing data on anthropomorphic changes in resource-limited settings primarily come from observational or cross-sectional studies. Data randomized clinical trials are needed to inform treatment decisions these areas of the world. Methods.  The AIDS Clinical Trials Group Prospective Evaluation Antiretrovirals Resource-Limited Settings (PEARLS) study was a prospective, evaluation efficacy emtricitabine/tenofovir + efavirenz (FTC/TDF EFV) vs lamivudine/zidovudine (3TC/ZDV for initial human immunodeficiency virus (HIV)-1-infected individuals resource-diverse settings. Changes measures were analyzed using mixed-effect models repeated measurements, all available measurements at weeks 48, 96, and 144. Intent-to-treat results presented; as-treated similar. Results.  Five hundred twenty-six participants FTC/TDF EFV, 519 3TC/ZDV EFV. Significantly greater increases baseline week 144 seen among those EFV except waist-to-hip ratio, with following mean changes: weight, 4.8 3.0 kg; body mass index, 1.8 1.1 kg/m(2); mid-arm, 1.7 0.7 cm; waist, 5.2 4.3 hip, 3.8 1.4 mid-thigh circumference, 3.1 0.9 cm. There 7 diagnoses lipoatrophy arm compared none arm. The proportion overweight obese increased 25% (week 0) 42% 144) 26% 38% Conclusions.  Our findings support first-line use emphasize need interventions limit weight gain HIV-infected