Speciated High-Density Lipoprotein Biogenesis and Functionality

摘要: Plasma high-density lipoprotein cholesterol (HDL-C) concentration is a negative risk factor for atherosclerotic cardiovascular disease (CVD). Despite this, most attempts to raise plasma HDL-C concentrations in cardioprotective way have failed. Recently, hypotheses about the atheroprotective effects of HDL shifted away from quantity quality, mostly function reverse transport. CVD patients poorer acceptor cellular than healthy controls, independent concentrations. The likely determined by two other factors, stability and composition. kinetic instability HDL, which varies according subclass, determinant its reactivity response many HDL-modifying activities. composition also heterogeneous variable; all particles contain apo AI but only two-thirds AII. This occurs despite fact that AII are hepatically secreted on separate later fuse plasma. contains traces proteins, some not yet been associated with function. One minor species those intact signal peptides, enhances their binding HDL; these special properties Here, we review provide perspective what currently known speciated biogenesis context health disease.